Efna5 Antibody, FITC conjugated

^{Rare Species}

Datasheet

Code	CSB-PA007464LC01RA
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Efna5 Polyclonal antibody

Uniprot No.

P97605

Target Names

Efna5

Alternative Names

Efna5 antibody; Eplg7 antibody; Lerk7 antibody; Ephrin-A5 antibody; AL-1 antibody; EPH-related receptor tyrosine kinase ligand 7 antibody; LERK-7 antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Ephrin-A5 protein (21-203AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Gene References into Functions

Changes in ephrinA5/EphA5 interactions within the ventromedial hypothalamus act in concert with islets to restore glucose homeostasis during acute hypoglycemia, and its effect on counterregulation may be mediated by changes in glutamate/glutamine cycling. PMID: 23274893
preservation of a nasal(low)-temporal(high) EphA5 gradient in retinal ganglion cell in neurons in superior colliculus in nerve graft PMID: 17328773

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor.

Protein Families

Ephrin family

Tissue Specificity

Expressed in brain, heart, placenta and lung.

Database Links

KEGG: rno:116683

STRING: 10116.ENSRNOP00000039406

UniGene: Rn.10714

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Related pathways

MAPK signaling pathway PI3K-Akt signaling pathway Ras signaling pathway Rap1 signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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